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KMID : 0816119980010010030
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Korean Journal of Pediatric Gastroenterolology and Nutrition
1998 Volume.1 No. 1 p.30 ~ p.36
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The Eradication of Helicobacter pylori in the Duodenal Ulcer in Children and the Duodenal Recurrence
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Choi Yon-Ho
Seo Jeong-Kee
Ko Jae-Sung
Kim Soon-Yeong
Yoo Young-Mee
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Abstract
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Purpose: It is well known that duodenal ulcer disease does not relapse if H. pylori is
cleared from the gastric mucosa. Little is known about the recurrence of duodenal ulcer
in children. The purpose of this study was to evaluate the effect of the eradication of
H. pylori in duodenal ulcer in children upon the duodenal ulcer recurrence.
Methods: 105 patients (M : F=78 : 27) diagnosed as duodenal ulcer by endoscopy in
1987∼1995 were reviewed clinically, and were parted into two groups. The two
treatment groups were ranitidine/antacid (RAN/ANT) and ranitidine/amoxicillin/denol
(RAN/AMX/D). The latter was for H. pylori -positive children with duodenal ulcer who
were diagnosed by serology and/or antral biopsies for histology, culture, and urease
testing. The recurrence rates were compared between the two groups.
Results: 1) 30 patients with primary duodenal ulcer underwent endoscopy for H. pylori
and 27(90.0%) of them were positive for H. pylori. 2) 27 of H. pylori-positive children
received RAN/AMX/D. 23(85.2%) of them showed cure of duodenal ulcer and eradication
of H. pylori. 3) The duodenal ulcer recurrence rate in RAN/ANT group was 65.3% and
the rate in RAN/AMX/D was 4.3% by a year.
Conclusions: There is a strong correlation between the duodenal ulceration and H.
pylori infection in children, and the eradication of H. pylori in duodenal ulcer patients
reduces the recurrence of the ulcer. Because of the low incidence of duodenal ulcers in
children, a multicenter prospective study is required to determine the effect of treating
H. pylori infection on the long term natural history of duodenal ulcer disease.
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KEYWORD
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H. pylori, Duodenal ulcer, Child,
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